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Cholestatic hepatitis due to Salmonella typhi

Ayse Albayrak, Sibel Seda Gunbey, Ferda Aktas
  • Ayse Albayrak
    Department of Infectious Diseases and Clinical Microbiology, Erzurum Region Education and Research Hospital, Erzurum, Turkey., Turkey | aysealbayrakerz@gmail.com
  • Sibel Seda Gunbey
    Department of Infectious Diseases and Clinical Microbiology, Erzurum Region Education and Research Hospital, Erzurum, Turkey., Turkey
  • Ferda Aktas
    Department of Clinical Microbiology, Erzurum Region Education and Research Hospital, Turkey, Turkey

Abstract

Salmonella infection occurs worldwide and is still an important public health problem in many developing countries. The infection can affect almost all major organs including the liver. Severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. In this paper, a 39-year-old male with acute cholestatic typhoid hepatitis is presented. The case had a tender hepatomegaly and elevated serum alanine and aspartate transaminase, alkaline phosphatase, and gamma glutamyl transferase levels; these features cannot been distinguished from those of acute viral hepatitis. Serological and viral markers of acute viral hepatitis were negative. No pathology could be determined in abdomen Ultrasonography (USG) or Magnetic Reso - nance (MR) Cholangiography. As enteric fever is a common infection, the recognition of salmonella hepatitis is of clinical importance. When patients from an endemic or outbreak area present acute febrile hepatitis, typhoid fever should be a consideration.

Keywords

typhoid fever, acute hepatitis, Salmonella typhi, ceftriaxone.

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Submitted: 2011-03-12 20:11:23
Published: 2011-04-11 18:58:02
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Copyright (c) 2011 Ayse Albayrak, Sibel Seda Gunbey, Ferda Aktas

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