Immune mediated necrotizing myopathy: A rare complication of statin therapy

Abstract

Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia, and elevated creatinine kinase levels, and was subsequently found to have anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies with a necrotizing process on muscle biopsy. This patient’s case was further complicated by sequelae of multiple disease processes, ultimately leading to deterioration of his health.

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Published
2020-06-30
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Issue
Section
Case Reports
Keywords:
Immune mediated necrotizing myopathy, statins, statin-induced IMNM, inflammatory myopathy.
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How to Cite
Abusharar, S. P., Moku, P., Banks, S., Khalid, F. M., Specht, C. S., & Polimera, H. V. (2020). Immune mediated necrotizing myopathy: A rare complication of statin therapy. Clinics and Practice, 10(2). https://doi.org/10.4081/cp.2020.1248