Pure red cell aplasia and associated thymoma

  • Cristian Rosu Cardiac surgery resident University of Montreal, Canada, Canada.
  • Sandra Cohen Division of hematology-oncology Maisonneuve-Rosemont Hospital University of Montreal, Canada.
  • Caroline Meunier Department of Pathology Maisonneuve-Rosemont Hospital University of Montreal, Canada.
  • Denise Ouellette Division of thoracic surgery Maisonneuve-Rosemont Hospital University of Montreal, Canada.
  • Gilles Beauchamp Division of thoracic surgery Maisonneuve-Rosemont Hospital University of Montreal, Canada.
  • George Rakovich | george.rakovich@umontreal.ca Division of thoracic surgery Maisonneuve-Rosemont Hospital University of Montreal, Canada.

Abstract

Pure red cell aplasia is a rare cause of anemia, caused by an absence of red blood cell precursors in the bone marrow. It is usually a paraneoplastic syndrome, associated most commonly with large-cell granular lymphocyte leukemia but also thymoma. For patients who present both pure red cell aplasia and thymoma, thymectomy leads to an initial remission of the aplasia in 30% of cases. However, sustained remission may require the addition of medications such as corticosteroids, cyclospo­rine, or cyclophosphamide. We present a case of pure red cell aplasia associated with a thymoma in an otherwise healthy 80 year-old woman.

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Published
2011-04-01
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Issue
Section
Case Reports
Keywords:
Anemia, pure red cell aplasia, thymoma, paraneoplastic syndrome
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How to Cite
Rosu, C., Cohen, S., Meunier, C., Ouellette, D., Beauchamp, G., & Rakovich, G. (2011). Pure red cell aplasia and associated thymoma. Clinics and Practice, 1(1), e1. https://doi.org/10.4081/cp.2011.e1