Early viral kinetics and response to treatment in a hepatitis C virus genotype 5 infected patient

  • Emanuele Durante-Mangoni | emanuele.durante@unina2.it Internal Medicine, 2nd University of Naples, Italy.
  • Domenico Iossa Internal Medicine, 2nd University of Naples, Italy.
  • Umberto Malgeri Internal Medicine, 2nd University of Naples, Italy.

Abstract

Genotype 5 hepatitis C has been poorly studied despite its worldwide spread. We have analyzed the early kinetics of genotype 5 hepatitis C virus RNA during pegylated interferon/ribavirin treatment in a 59-year-old man with active liver necroinflammatory changes and advanced liver fibrosis. The patient had a high viral load but a small serum level of hepatitis C core antigen. On combination antiviral treatment with pegylated-interferon alpha 2a, 180 ?g/week, and ribavirin, 1200 mg/day, the patient experienced an impressive reduction in serum HCV RNA as early as day 2 of treatment and eventually became a sustained virological responder. Our viral kinetics data support previous clinical studies showing HCV genotype 5 could be as intrinsically sensitive to interferon as HCV genotypes 2 and 3.

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Author Biography

Emanuele Durante-Mangoni, Internal Medicine, 2nd University of Naples

Assistent Professor

Chairs of Internal Medicine

2nd University of Naples Medical School

 

Published
2011-04-29
Info
Issue
Section
Case Reports
Keywords:
hepatitis C, chronic, pegylated interferon alpha-2a, ribavirin, treatment outcome.
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How to Cite
Durante-Mangoni, E., Iossa, D., & Malgeri, U. (2011). Early viral kinetics and response to treatment in a hepatitis C virus genotype 5 infected patient. Clinics and Practice, 1(2), e28. https://doi.org/10.4081/cp.2011.e28