First trimester diagnosis of VACTERL association

  • Joana Santos | j.asantos@sapo.pt Department of Obstetrics and Gynecology, São Teotónio Hospital, Viseu, Portugal.
  • Rosete Nogueira Laboratory of Anatomic Pathology, CGC Genetics, Porto, Portugal.
  • Rita Pinto Department of Obstetrics and Gynecology, São Teotónio Hospital, Viseu, Portugal.
  • Isabel Cerveira Department of Obstetrics and Gynecology, São Teotónio Hospital, Viseu, Portugal.
  • Susana Pereira Department of Obstetrics and Gynecology, São Teotónio Hospital, Viseu, Portugal.

Abstract

VACTERL association (OMIM 192350) is a non-random combination of multiple congenital malformations including vertebral, anal, cardiac, tracheoesophageal, renal and limb anomalies. The wide spectrum of defects suggests the occurrence of defective development during early embryogenesis. The authors report a case of a complex polymalformative association detected by ultrasound in the first trimester of pregnancy. The ensuing fetal study revealed the presence of vertebral, anorectal, renal and limb anomalies and therefore was considered a case of VACTERL association. This complex association generally entails a poor prognosis. Its early detection allows discussion of management options, including medical termination of pregnancy.

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Published
2013-02-05
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Section
Case Reports
Keywords:
VACTERL association, VATER association, first trimester diagnosis.
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How to Cite
Santos, J., Nogueira, R., Pinto, R., Cerveira, I., & Pereira, S. (2013). First trimester diagnosis of VACTERL association. Clinics and Practice, 3(1), e5. https://doi.org/10.4081/cp.2013.e5